Preheat your oven to a toasty 350°F. Lightly spray a 9×13 baking dish and set it aside to prepare for the deliciousness ahead.
In a heavy-bottomed stock pot that holds about 4-5 quarts, brown the ground beef along with the diced yellow onion over medium-high heat. Once the meat is nicely browned, drain any excess grease—then return the mixture to the pot.
Add in those delightful cans of Manwich sauce, the cooked farfalle noodles, and the creamy Velveeta cheese. Give everything a good stir until all the ingredients are combined and enveloped in that sumptuous sauce.
Pour the mixture into your prepared baking dish and smooth it out.
Sprinkle a generous layer of shredded Colby-Jack cheese on top to ensure every bite is rich and gooey.
Place the dish in the oven and bake for about 25 minutes, or until the cheese is melted and bubbling with joy.
Once done, carefully take it out of the oven and allow it to cool slightly – this is crucial!
Serve your warm Sloppy Joe Casserole and savor the comforting flavors that fill your home.